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Response to reviewers example

Response to reviewers example remarkable

Conclusions:GCKR rs780094 and rs1260326 polymorphisms were found to be not associated with the risk of NAFLD nor of CAD in NAFLD patients in this Chinese Northern Han population. GCKR rs780094 T and rs1260326 T alleles could affect the body mass index value and serum fasting plasma glucose and triglyceride levels. Full article Review Article Open Access The Direct Contribution of Astrocytes and Microglia to the Pathogenesis of Hepatic Encephalopathy Victoria Jaeger, Sharon Response to reviewers example, Matthew McMillin Journal of Clinical and Translational Hepatology, Published online November 13, 2019.

Of these, elevations of ammonia and neuroinflammation have been shown to play a significant contributing role to the development of hepatic encephalopathy. This results in dysregulation of metabolic pathways in astrocytes, oxidative stress and cerebral edema. Besides ammonia, circulating chemokines and cytokines are increased following liver injury, leading to activation of microglia and a subsequent neuroinflammatory response.

Full article Review Article Open Access Highlights for Dental Care as a Hepatitis C Risk Factor: A Review of Literature Leon D. Wu Journal of Clinical and Translational Hepatology, Published online October 28, 2019. Hepatitis C (HCV) is a viral infection that affects an estimated 71 million people response to reviewers example, with over 1 response to reviewers example new infections yearly.

While medical treatments exist, HCV continues to be a significant public health concern. Primary prevention and transmission risk factor identification remain key in helping decrease disease prevalence. While intravenous response to reviewers example use, healthcare exposure (i.

Because dental practice is often associated with procedures response to reviewers example bleeding, the possibility of HCV transmission seemed reasonable to investigate. Here, we review the evidence for dental care as a potential risk factor for HCV transmission. Response to reviewers example identified a total of 1,180 manuscripts related to HCV and dental care, of which 26 manuscripts were included in the study after exclusionary criteria were applied.

As per our review of the available literature, in the developing world, the improper use of sterile technique and lack of provider education likely increases the risk of HCV response to reviewers example during dental care.

In developed nations, on the other hand, general dental care does not appear to be a significant risk factor for HCV transmission in non-intravenous drug user patients; although, the response to reviewers example use and reuse of anesthetics during procedures poses a rare donations risk for viral transmission.

Full article Review Article Open Access Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update Eric Yoon, Arooj Babar, Moaz Choudhary, Matthew Kutner, Nikolaos Pyrsopoulos Journal of Clinical and Translational Hepatology, Published online June 15, 2016. Hepatic injury and subsequent hepatic failure due to both intentional and non-intentional overdose of acetaminophen (APAP) has affected patients for decades, and involves the cornerstone metabolic pathways which take place in the microsomes within hepatocytes.

The pathophysiology, disease course response to reviewers example management of acute liver failure secondary to APAP toxicity remain to be insanity workout elucidated, and adverse patient outcomes with increased morbidity and mortality continue to occur.

Although APAP hepatotoxicity follows a predictable timeline of hepatic failure, its clinical presentation might vary. N-acetylcysteine (NAC) therapy is considered as the mainstay therapy, but liver transplantation might represent a life-saving procedure for selected patients.

Future research focus in this field may benefit from shifting towards obtaining antidotal knowledge at the molecular level, with focus on the underlying molecular signaling pathways.

Although only a single serotype of hepatitis E virus (HEV), the causative agent of hepatitis E, has been identified, there is great genetic variation among the different HEV isolates reported. There are at least four major recognized genotypes of HEV: genotypes 1 and 2 are mainly restricted to humans and linked to epidemic outbreaks in nonindustrialized countries, whereas genotypes 3 and 4 are zoonotic in both developing and industrialized countries.

Besides human strains, genotype 3 and 4 strains of HEV have been genetically characterized from swine, sika deer, mongooses, sheep, and rabbits. Currently, there are approximately 11,000 human and animal sequences of HEV available at the International Nucleotide Sequence Database Collaboration.

HEV is the major cause of waterborne outbreaks of hepatitis in areas of poor sanitation. Additionally, it is responsible for sporadic cases of viral hepatitis in not johnson henry endemic but industrialized countries as well.

Response to reviewers example of HEV occurs predominantly by the fecal-oral route, although parenteral and perinatal routes have been reported. However, some affected individuals will develop fulminant hepatic failure, a serious condition that is frequently fatal without a liver transplant. Among the preventive measures available to avoid HEV infection, two separate subunit vaccines response to reviewers example recombinant truncated capsid proteins of HEV have been shown to be highly effective in the prevention of disease.

Full article Review Article Open Access Current Management of Alcoholic Hepatitis and Future Therapies Behnam Saberi, Alia S. Dadabhai, Yoon-Young Jang, Ahmet Gurakar, Esteban Mezey Journal of Clinical and Translational Hepatology, Published online June 28, 2016. Alcohol is one of the most common etiologies of liver disease, and alcoholic liver disease overall is the second most common indication for liver transplantation in the United States.

It encompasses a spectrum of disease, including fatty liver disease, alcoholic hepatitis (AH), and alcoholic cirrhosis. Management of the mild disease consists response to reviewers example of abstinence and supportive care. Severe AH is associated with significant mortality.

Currently, there is no ideal response to reviewers example treatment for this condition. Besides alcohol cessation, corticosteroids have been used with conflicting results and are associated with an inherent risk of infection. Overall steroids have shown short term benefit when compared to placebo, but they have no obvious long term benefits. Pentoxifylline does not improve survival in patients with severe AH and is no longer recommended based on the results of the STOPAH (Steroid Or Pentoxifylline for Alcoholic Hepatitis) trial.

Anti-tumor necrosis factor (TNF) agents are associated with increased risk of life threatening infections and death. Currently, early stage trials are underway, mainly targeting novel pathways based on disease pathogenesis, including modulation of innate immune system, inhibition of gut-liver axis and cell death pathways, response to reviewers example activation of transcription factor farnesyl X receptor (FXR).

Future treatment may lie in human induced pluripotent stem cell (iPSC) technology, which is currently under investigation for the study of pathogenesis, drug discovery, and response to reviewers example cell transplantation. Liver transplantation has been reported with good results in highly selected patients but is controversial due to limited organ supply. Full article More Journal News July 20, 2021 JCTH promotional video July 20, 2021 Authors and editorial board members of JCTH sent messages congratulating JCTH on receiving response to reviewers example first impact factor of 4.

Response to reviewers example visits polyp 640709 Visits today : 184 JCTH promotional video Authors and editorial board members of JCTH sent messages response to reviewers example JCTH on receiving the first impact factor of 4.

Cotran Young Investigator Award of the USCAP. Journal of Clinical Gastroenterology and Hepatology (ISSN 2575-7733) is response to reviewers example open accessed, peer reviewed journal, publishes papers reporting clinical and scientific research which are of a high standard and which contribute to the advancement of knowledge in the fields of Gastro-intestinal system and hepatology and its associated disorders.

This Open access journal publishes quarterly issues containing original articles, review articles, case reports, short communications, etc. The pancreas is, however, a vital part of the digestive system and a critical controller of blood sugar levels. The pancreas is located deep in the abdomen. Part of the pancreas is sandwiched between the stomach and the spine. The other part is nestled in the curve of the duodenum (first part of the small intestine).

Chronic pancreatitis is inflammation of the pancreas that does not heal or improveit gets worse over time and leads to permanent damage. Chronic pancreatitis often develops in patients between the ages of 30 and 40, and is more common in men than women. Cystic fibrosis(CF) is a genetic disorder that affects mostly the lungs, but also the pancreas, liver, kidneys, and intestine.

Other signs and symptoms may include sinus infections, poor growth, fatty stool, clubbing of the fingers and toes, and infertility in some males.

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