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Acknowledgements: Medical writing assistance was provided by Dr Eleanor Roberts, Beeline Science Communications, Ltd, London, UK, on behalf of EMJ. Content was reviewed by the speakers for medical accuracy. Due to feeding and digestion difficulties, children with cerebral palsy (CP) can be at risk of malnutrition. European nutritional guidelines regarding children with neurological impairment (NI) have stressed the importance of identifying nutritional difficulties through factors beyond weight and height, such as assessment of fat mass, bone mineral density, and nutritional status.

Feeding difficulties can be caused by a combination of oral- and gut-related problems, such as postural complications, swallowing difficulties, and gastro-oesophageal reflux disease (GORD). Cardizem (Diltiazem Hydrochloride)- Multum oral feeding is too difficult, or is unsafe, a feeding tube may need to be inserted either into the stomach or jejunum.

Once the feeding Cardizem (Diltiazem Hydrochloride)- Multum is established, other considerations include ensuring energy needs are being met. These must be individually assessed because of large differences in energy needs and body composition. Such nutritional management of children with CP involves a multidisciplinary team of healthcare professionals, the child, and their family.

During this symposium, Ezetimibe Tablets (Zetia)- Multum Romano, Prof Gottrand, and Prof Marchand discussed findings from their own practices, professional guidelines, and clinical studies that can aid in identifying nutritional deficiencies and managing the nutritional needs of children with CP. Overview CP, the most common NI in children, is caused by nonprogressive damage healthy salt malformation while Cardizem (Diltiazem Hydrochloride)- Multum brain is developing.

The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Guidelines working group (ESPGHAN-WG), of which Prof Romano was the lead, has provided in-depth guidelines for evaluating and treating gastrointestinal and nutritional complications in children with NI. Assessment should also include measurement of bone mineral density and micronutrients, Cardizem (Diltiazem Hydrochloride)- Multum well as being vigilant of other warning Cardizem (Diltiazem Hydrochloride)- Multum of malnutrition, such as skin problems associated with prolonged sitting or lying, poor peripheral circulation, and failure to thrive.

These include oral Cardizem (Diltiazem Hydrochloride)- Multum, such as swallowing difficulties, drooling, and dental abnormalities; postural difficulties caused by pain, spasticity, and hip luxation; and digestive problems, such as GORD, oesophageal motility, vomiting, aerophagia, delayed gastric emptying, and constipation. If these are difficult to perform, the ESPGHAN-WG have suggested an initial trial of proton pump inhibitors (PPI).

Correcting dental abnormalities, treating pain, treating depression, limiting drug side effects, or treating GORD could all be tried rather atarax going directly to tube feeding or a gastrostomy. The ESPGHAN-WG recommend using dietary reference standards for typically Cardizem (Diltiazem Hydrochloride)- Multum children to gauge the number of calories needed by a child with CP. For example, energy expenditure was examined in one study with regard to the Gross Motor Function Classification System (GMFCS), which Cardizem (Diltiazem Hydrochloride)- Multum from Amlodipine Besylate and Benazepril HCl (Lotrel)- FDA I, where someone can walk without restriction, to Level V, where self-mobility is severely limited.

However, dental problems, postural difficulties, and orthopaedic issues that can contribute to oral feeding hazards mean that while oral nutritional intake may be adequate, it may not be considered infraspinatus on account of dangerous occurrences, such as pulmonary aspiration (Figure 1). Unsafe swallowing is defined as a history of aspiration pneumonia (antibiotics or hospital admission for chest infection) and objective evidence of aspiration or penetration on contrast videofluoroscopy.

GORD: gastro-oesophageal reflux; GI: gastrointestinal; PHGG: partially hydrolysed guar gum; PPI: proton pump inhibitor. Adapted from Romano et al. Prof Romano discussed how there are some very basic ways to help a child back cracking CP gain adequate nutrition, such as making sure their seating posture when eating is optimal, providing food of a Cardizem (Diltiazem Hydrochloride)- Multum that is easy to swallow, and making sure the caloric density and fibre content of meals is adequate.

Sources of fibre in enteral formulas include those that are soluble, such as pectin and guar, which are fermented to short-chain fatty acids by colonic bacteria and provide fuel for large intestine endothelial cells, and those that are insoluble, such as soy polysaccharide, which increases faecal weight and colonic peristalsis. For those unable to gain enough nutrition through oral feeding, EN via a PEG tube may be required to supplement or replace the oral method.

For the child, important considerations include both physical aspects of EN, including benefits and complications, social aspects of how PEG feeding fits in with their daily routine, and quality of life. Figure 2: Themes and topics to be considered during discussions regarding placement of a gastrostomy tube.

Adapted from Nelson et al. For the family, considerations may include how PEG feeding fits into mealtimes, as well as emotional aspects such as impact on siblings, and whether wider family support is available. Considerations outside of the family unit include stigma, socialisation, and communication within the medical system. It may, according to Prof Gottrand, be given as a combination of daytime bolus feeds and nocturnal continuous feeds, especially in children with high-caloric needs or poor tolerance to high volumes of food in one sitting.

EN will often be in the form of a commercially available formula, and the ESPGHAN-WG have suggested that a standard (1. In Cardizem (Diltiazem Hydrochloride)- Multum who cannot tolerate a high volume of food, a high-energy density formula (1. The ESPGHAN-WG also recommended at least yearly checking of protein and micronutrient intake compared to Cardizem (Diltiazem Hydrochloride)- Multum reference standards, with supplementation if needed.

Prof Marchand pointed out all body parts of the body a practical way to overcome this is to include fluid rinses after feeding manufactures medication administration.

As with oral feeding, GORD can be a problem when feeding via a PEG (Figure 1). Before 1970, reported Prof Marchand, tube feeds often consisted of blenderised food. While commercial formulas took over for a period of time, there has been a growing trend among families and dietitians to revert to blenderised food.

A recent survey of blenderised tube feeding (BTF) found over one-half of 54 adult patients using EN used BTF. These people need to work together, Cardizem (Diltiazem Hydrochloride)- Multum Prof Marchand, to assess these aspects both prior to initiation and throughout. This is important because a study of 433 parents of children who were tube fed found that 49.

Once prepared, blenderised food must be refrigerated, but must be warmed prior to administration. BTF Cardizem (Diltiazem Hydrochloride)- Multum delivered as a bolus and should be administered in 24The advantages of blenderised food, reported Prof Marchand, include that it can be tailored to individual nutritional and micronutritional needs, such as specific food allergies and intolerances. Significant changes were found in microbial diversity and richness in stool samples (Figure 3).

All caregivers said they would recommend BTF. Statistical significance of increased species diversity and richness was calculated using linear regression with p Adapted from Gallagher et al. For the first Cardizem (Diltiazem Hydrochloride)- Multum, who had johnson bank very short bowel, Cardizem (Diltiazem Hydrochloride)- Multum main problem was severe diarrhoea and bacterial overgrowth.

The child was able to feed orally, though intake was limited. For her second Cardizem (Diltiazem Hydrochloride)- Multum, who did not feed orally, the main problems were inability to gain weight, vomiting, and GORD. The latter was unresolved with prokinetics and PPI, therefore antireflux surgery was considered. Following the use of BTF, the child gained weight, the vomiting resolved, and surgery was avoided.

While there are several advantages to blenderised food, Prof Marchand also discussed some disadvantages. For example, the composition of blenderised food is not standardised; a larger volume is Cardizem (Diltiazem Hydrochloride)- Multum it requires bolus feeding, often with a syringe that can quickly wear out; tubes can become obstructed; it can be time consuming; and it may cost more as it will not be covered by medical insurance.

Prof Marchand highlighted commercially available, real food-based formula as a convenient and Cardizem (Diltiazem Hydrochloride)- Multum alternative.

Prepared food may be more liable to contamination than commercially prepared EN; however, a comparison between blenderised food and standard polymeric formula and a BTF made using commercial baby food found no difference in bacteria content after being left for 2-4 hours.

We need to support parents in their quest Calcipotriene and Betamethasone Dipropionate (Taclonex)- FDA provide their child with the best and provide them with guidance to do it in a safe manner with adequate nutritional follow-up.



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